Journal Title
Title of Journal: J Incl Phenom Macrocycl Chem
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Abbravation: Journal of Inclusion Phenomena and Macrocyclic Chemistry
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Publisher
Springer Netherlands
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Authors: Ajay Semalty Mona Semalty Devendra Singh M S M Rawat
Publish Date: 2009/11/19
Volume: 67, Issue: 3-4, Pages: 253-260
Abstract
Naringenin is a flavonoid specific to citrus fruits and possesses antiinflammatory anticarcinogenic and antitumour effects But due to a lower halflife and rapid clearance from the body frequent administration of the molecule is required To improve the bioavailability and prolong its duration in body system its phospholipid complexes were prepared by a simple and reproducible method Naringenin was complexed with phosphatidylcholine in equimolar ratio in presence of dichloromethane The prepared Phytosomes naringenin–phospholipid complex were evaluated for various physical parameters like FTIR spectroscopy Differential Scanning Calorimetry DSC Xray powder diffractometry XRPD Solubility Scanning Electron Microscopy SEM and the in vitro drug release study These phospholipid complexes of naringenin were found to be irregular and disc shaped with rough surface in SEM Drug content was found to be 917 w/w FTIR 1H NMR DSC and XRPD data confirmed the formation of phospholipid complex Water solubility of naringenin improved from 4383 to 7931 μg/mL in the prepared complex Unlike the free naringenin which showed a total of only 27 drug release at the end of 10 h naringenin complex showed 9980 release at the end of 10 h of dissolution study Thus it can be concluded that the phospholipid complex of naringenin may be of potential use for improving bioavailabilityAuthors acknowledge the grant provided by the Department of Science and Technology Govt of India for the research work Authors are also thankful to LIPOID GmbH Germany for providing the gift sample of phosphatidylcholine for the research work Facilities provided by the UGCDAE Consortium for Scientific Research Indore MP and Department of Chemistry University of Delhi are thankfully acknowledged
Keywords:
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- β-Cyclodextrin/protein conjugates as a innovative drug systems: synthesis and MS investigation
- Pre-formulation of an oral cyclosporine free of surfactant
- Vibrational dynamics and hydrogen bond properties of β-CD nanosponges: an FTIR-ATR, Raman and solid-state NMR spectroscopic study
- Improved aqueous Cannizzaro reaction in presence of cyclodextrin
- The solid-state structures of the ethanol solvated complexes of para -sulphonato-calix[4]arene with magnesium and calcium ions
- Design and evaluation of folate-appended methyl-β-cyclodextrin as a new antitumor agent
- 8-Hydroxyquinoline Based Multipodal Systems: Effect of Spatial Placement of 8-Hydroxyquinoline on Metal Ion Recognition
- Thiacalixarenes: emergent supramolecules in crystal engineering and molecular recognition
- Synthesis and characterization of new organocobaloxime derivatives with asymmetric dioxime ligands
- Encapsulation and Release Characteristics of Carbon Dioxide in α-Cyclodextrin
- Molecular dynamics simulation and quantum chemical studies on the investigation of aluminum nitride nanotube as phosgene gas sensor
- Synthesis, structure and property of three divalent metal complexes of the piperidinoacetyl-containing calix[4]arene
- In vitro evaluation of the cytotoxicity of a folate-modified β-cyclodextrin as a new anti-cancer drug delivery system
- Sorption onto insoluble β-cyclodextrin polymer for 2,4-dinitrophenol
- Glycation of human serum albumin affects its binding affinity towards (−)-epigallocatechin gallate
- Organotellurium-bridged cyclodextrin dimers as artificial glutathione peroxidase models
- Interactions of cyclodextrins with aromatic amino acids: a basis for protein interactions
- Naphthyridine amide–urea conjugate: a case toward selective fluorometric sensing of N -acetyl proline carboxylate
- A novel switch-on fluorescent receptor for bromide based on an amide group
- Thermodynamics of ZrO 2+ cation complexation with dibenzo-18-crown-6 in mixed non-aqueous solvents
- A computational study of hydrogen cyanide interaction with the pristine and B, Ga, BGa-doped of (8, 0) zigzag AlPNTs
- Selective Pseudo-Rotaxane Type Complex Formation of Zinc(II) ( t -butylatedtetraphenyl) porphyrin-Viologen Linked Compounds with tri- O -methyl-β-Cyclodextrin
- Controlled release of antifungal volatiles of thyme essential oil from β-cyclodextrin capsules
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- Sorption of azo dyes from aqueous solutions by tetradodecyloxybenzylcalix[4]resorcinarene derivatives
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- Determination of the ionization constants of natural cyclodextrins by high-resolution 1 H-NMR and photon correlation spectroscopy
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- Inclusion complex formation of α- and β-cyclodextrins with aminobenzoic acids in aqueous solution studied by 1 H NMR
- Preparation of a cyclodextrin dimer linked with a bis(picolinyl)cystine moiety and its intra- and intermolecular inclusion behavior
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