MKP1 regulates the induction of MCP1 by Emphasis

Authors: HeeSung Shin InHwa Yoo YongJae Kim JiYun Lee HyongBai Kim Shouguang Jin UnHwan Ha

Publish Date: 2010/08/23

Volume: 30, Issue: 3, Pages: 263-270

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Abstract

Epithelial cells act as the first line of host defense against microbes by producing a range of different molecules for clearance Chemokines facilitate the clearance of invaders through the recruitment of leukocytes Thus upregulation of chemokine expression represents an important innate host defense response against invading microbes such as Streptococcus pneumoniae In this study we report that the expression of Monocyte Chemotactic Protein 1 MCP1 was highly induced in response to S pneumoniae in vitro and in vivo Among numerous virulence factors pneumococcal pneumolysin was found to be the major factor responsible for this induction Furthermore MCP1 induction was mediated by the p38 mitogenactivated protein kinase MAPK whose activation was controlled by MAPK phosphatase 1 MKP1 Therefore this study reveals novel roles of pneumolysin in mediating MKP1 expression for the regulation of MCP1 expression in human epithelial cells

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