Journal Title
Title of Journal: Mol Cells
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Abbravation: Molecules and Cells
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Publisher
Springer Netherlands
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Authors: Hyung Wook Nam Robert C Bruner DooSup Choi
Publish Date: 2013/08/01
Volume: 36, Issue: 3, Pages: 195-202
Abstract
Adenosine signaling has been implicated in the pathophysiology of alcohol use disorders and other psychiatric disorders such as anxiety and depression Numerous studies have indicated a role for A1 receptors A1R in acute ethanolinduced motor incoordination while A2A receptors A2AR mainly regulate the rewarding effect of ethanol in mice Recent findings have demonstrated that dampened A2ARmediated signaling in the dorsomedial striatum DMS promotes ethanolseeking behaviors Moreover decreased A2AR function is associated with decreased CREB activity in the DMS which enhances goaloriented behaviors and contributes to excessive ethanol drinking in mice Interestingly caffeine the most commonly used psychoactive substance is known to inhibit both the A1R and A2AR This dampened adenosine receptor function may mask some of the acute intoxicating effects of ethanol Furthermore based on the fact that A2AR activity plays a role in goaldirected behavior caffeine may also promote ethanolseeking behavior The A2AR is enriched in the striatum and exclusively expressed in striatopallidal neurons which may be responsible for the regulation of inhibitory behavioral control over drug rewarding processes through the indirect pathway of the basal ganglia circuit Furthermore the antagonistic interactions between adenosine and dopamine receptors in the striatum also play an integral role in alcoholism and addictionrelated disorders This review focuses on regulation of adenosine signaling in striatal circuits and the possible implication of caffeine in goaldirected behaviors and addiction
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