fMRI memory assessment in healthy subjects a new

Authors: Maria Strandberg Christina Elfgren Peter Mannfolk Johan Olsrud Lars Stenberg Danielle van Westen ElnaMarie Larsson Ia Rorsman Kristina Källén

Publish Date: 2010/09/23

Volume: 5, Issue: 1, Pages: 1-11

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Abstract

We present a comprehensive and clinically applicable fMRI test—including both a verbal and a visuospatial task—for assessment of hemispheric specific memory in the medial temporal lobe MTL fMRI data was collected from 15 healthy righthanded volunteers Wholebrain activation was analyzed as well as activation in two regions of interest the MTL and the anterior speech area Laterality indices LI and LIcurves were calculated using the LI toolbox of Wilke and Lidzba 2007 The fMRI paradigms successfully visualized memoryrelated activity in the MTL the verbal memory measure also provided information of language lateralization Eleven subjects showed left lateralized verbal encoding in the MTL visuospatial memory activation was divided equally between left and right and 14/15 subjects had left lateralized language Lateralization data at the group level were consistent with previous studies but a variety of activation effects were found at the individual level indicating differences in strategy during verbal and visuospatial processing Further studies using the presented method are needed to determine its clinical usefulnessThis research was financially supported by the University Hospital in Lund Sweden and by grant from the Swedish Research Council projects no 42120051678 The authors thank the staff at the Department of Radiology at the University Hospital of Lund Sweden for their contribution to the research They also thank Anthony Waites Magnus Lindgren and Peter Höglund for their contributions to this paper

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