Journal Title
Title of Journal: Brain Imaging and Behavior
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Abbravation: Brain Imaging and Behavior
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Authors: Yuanchao Zhang Tao Fang Yue Wang Xin Guo Abdulqawi Alarefi Jian Wang Tianzi Jiang Jiuquan Zhang
Publish Date: 2016/01/16
Volume: 11, Issue: 1, Pages: 1-7
Abstract
Amyotrophic lateral sclerosis ALS is a fatal neurodegenerative disease characterized by progressive muscular weakness and atrophy Several morphometric studies have been conducted to investigate the gray matter volume or thickness changes in ALS whereas the cortical folding pattern remains poorly understood In the present study we applied a surfacebased local gyrification index LGI from high resolution MRI data to quantify the cortical folding in matched samples of 25 ALS patients versus 25 healthy controls Using restingstate fMRI data we further conducted seedbased functional connectivity analysis to explore the functional correlate of the cortical folding changes We found that ALS patients had significantly reduced LGI in right occipital cortex and that abnormality in this region associated with decreased functional connectivity in the bilateral precuneus This set of findings was speculated to result from disturbed white matter connectivity in ALS In the patient group we revealed significant negative correlations between disease duration and the LGIs of a cluster in the left superior frontal gyrus which may reflect the cognitive deterioration in ALS In summary our results suggest that LGI may provide a useful means to assess ALSrelated neurodegeneration and to study the pathophysiology of ALSAll procedures performed in this study of human participants were in accordance with the ethical standards of the institutional review board and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards Informed consent was obtained from all the participants The study was approved by the Medical Research Ethics Committee of Southwest Hospital The Third Military Medical University People’s Republic of ChinaThis work was funded by the National Basic Research Program of China 973 program Grant No 2011CB707800 the Natural Science Foundation of China Grant Nos 81101000 and Plan A of Science and Technology Support Program from Science and Technology Department of Sichuan Province Grant No 2014SZ0014
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