Subthalamic nucleus stimulation effects on single

Authors: Cyril AtkinsonClement Audrey Maillet Didier LeBars Franck Lavenne Jérôme Redouté Alexandre Krainik Pierre Pollak Stéphane Thobois Serge Pinto

Publish Date: 2016/10/04

Volume: 11, Issue: 4, Pages: 1139-1153

PDF Link

Abstract

Subthalamic nucleus deep brain stimulation STNDBS represents one of the most efficacious treatments for Parkinson’s disease along with Ldopa therapy The objective of the present work was to identify the cerebral networks associated with hand movement and speech production tasks performed alone and simultaneously as well as the effects of STNDBS on these profiles Clinical behavioral and neuroimaging oxygen 15labeled water and Positron Emission Tomography investigations were used to study single and combined performances of unilateral hand movements and speech production in 11 unmedicated individuals with PD both off and on STNDBS Specifically a flexible factorial design with the tasks hand movement speech production combined task and the STNDBS conditions off on as main factors was chosen for brain activation statistical analysis using a FamilyWise Error corrected pvalue at the cluster level of at least 10 contiguous voxels Increased activation of frontoparietal and cingulate areas was observed under STNDBS for hand movement in single and combined tasks respectively reflecting a partial restoration of corticosubcortical connections The lack of results for speech production for both off and on STNDBS could illustrate its relatively poor response to the treatment STNDBS tended to restore the additive function capacity that can be achieved when performing the combined task We confirmed with original neuroimaging data that speech is much less responsive to STNDBS than any other motor function and we concluded that speech outcomes following STNDBS can be different from those observed preoperatively following Ldopa administrationThe authors wish to thank all the patients who participated in this study They also wish to thank the PET/CERMEP team Véronique Berthier Jamila Lagha Christian Tourvielle Fabienne Vey Christine Vighi Luc Zimmer for their helpful support The authors also thank Ms Mignard for revising the English of the manuscriptThis study was supported financially by the French Health Ministry Programme Hospitalier de Recherche Clinique PHRC 2005 The authors declared that no competing interests exist the funders had no role in study design data collection analyses decision to publish or preparation of the manuscript C AC wishes to thank the PACA Regional Council and Orthomalin© PhD grant scheme cofunders AM also wishes to thank the Labex Cortex and the Fondation Neurodis for financial supportAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards

Keywords: