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Title of Journal: Brain Imaging and Behavior

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Abbravation: Brain Imaging and Behavior

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Springer US

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DOI

10.1007/s40278-013-4467-x

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1931-7565

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Relevance of neuroimaging for neurocognitive and b

Authors: Marsh Königs Petra JW Pouwels LW Ernest van Heurn Roel Bakx R Jeroen Vermeulen J Carel Goslings Bwee Tien PollThe Marleen van der Wees Coriene E CatsmanBerrevoets Jaap Oosterlaan
Publish Date: 2017/01/14
Volume: 12, Issue: 1, Pages: 29-43
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Abstract

This study aims to 1 investigate the neuropathology of mild to severe pediatric TBI and 2 elucidate the predictive value of conventional and innovative neuroimaging for functional outcome Children aged 8–14 years with trauma control TC injury n = 27 were compared to children with mild TBI and risk factors for complicated TBI mildRF+ n = 20 or moderate/severe TBI n = 17 at 28 years postinjury Neuroimaging measures included acute computed tomography CT volumetric analysis on postacute conventional T1weighted magnetic resonance imaging MRI and postacute diffusion tensor imaging DTI analyzed using tractbased spatial statistics and voxelwise regression Functional outcome was measured using Common Data Elements for neurocognitive and behavioral functioning The results show that intracranial pathology on acute CTscans was more prevalent after moderate/severe TBI 65 than after mildRF+ TBI 35 p = 035 while both groups had decreased white matter volume on conventional MRI ps ≤ 029 ds ≥ −074 The moderate/severe TBI group further showed decreased fractional anisotropy FA in a widespread cluster affecting all white matter tracts in which regional associations with neurocognitive functioning were observed FSIQ Digit Span and RAVLT Encoding that consistently involved the corpus callosum FA had superior predictive value for functional outcome ie intelligence attention and working memory encoding in verbal memory and internalizing problems relative to acute CTscanning ie internalizing problems and conventional MRI no predictive value We conclude that children with mildRF+ TBI and moderate/severe TBI are at risk of persistent white matter abnormality Furthermore DTI has superior predictive value for neurocognitive outcome relative to conventional neuroimaging


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