Journal Title
Title of Journal: Brain Imaging and Behavior
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Abbravation: Brain Imaging and Behavior
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Authors: Maria A Rocca Silvia Fumagalli Elisabetta Pagani Roberto Gatti Gianna C Riccitelli Paolo Preziosa Giancarlo Comi Andrea Falini Massimo Filippi
Publish Date: 2016/10/11
Volume: 11, Issue: 5, Pages: 1343-1352
Abstract
Action observation training AOT is thought to facilitate motor system function We applied voxelwise methods to assess the regional modifications of brain gray matter GM volumes and white matter WM architecture in healthy subjects following AOT and their correlations with improvements at motor and cognitive functional scales Fortytwo righhanded healthy subjects were randomized into an experimental AOTG n = 20 and a control CG n = 22 group The training lasted 2 weeks and consisted of 10 sessions of 45 min each during which subjects watched videos of dailylife actions AOTG or landscapes CG alternated by the execution with the right hand of actions presented in the AOTG videos At baseline and follow up motor and cognitive functional measures as well as brain structural MRI scans were obtained Tensorbased morphometry and tractbased spatial statistics were used to map longitudinal modifications of GM and WM structures and their correlation with functional scales After training both groups improved at cognitive tests whereas the AOTG also improved hand motor performance Following training no modifications of WM diffusion tensor MRI indexes were detected After training compared to CG AOTG had increased volume of the left superior frontal gyrus and decreased volume of the right lingual gyrus Compared to AOTG CG showed increased volume of the right middle frontal gyrus and left inferior temporal gyrus In AOTG GM volume changes correlated with improvements at cognitive tests Tenday AOT in healthy individuals modifies GM structure promoting structural brain plasticity and functional competenceAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards
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