Mitochondrial Dysfunction and Oxidative Damage to

Authors: Marina Bayeva Hossein Ardehali

Publish Date: 2010/09/24

Volume: 12, Issue: 6, Pages: 426-432

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Abstract

Hypertension is an important risk factor for the development of heart failure Increased production of reactive oxygen species ROS contributes to cardiac dysfunction by activating numerous prohypertrophic signaling cascades and damaging the mitochondria thus setting off a vicious cycle of ROS generation The way in which oxidative stress leads to exacerbation of systolic and diastolic dysfunction is still unclear however In skeletal muscle and ischemic myocardium increased ROS production causes preferential oxidation of myofibrillar proteins and provides a mechanistic link between oxidative damage and impaired contractility through disruption of actinmyosin interactions enzymatic functions calcium sensitivity and efficiency of crossbridge cycling In this review we summarize recent findings in the fields of heart failure and sarcomere biology and speculate that oxidative damage to myofibrils may contribute to the development of heart failure

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