Journal Title
Title of Journal: Curr Hypertens Rep
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Abbravation: Current Hypertension Reports
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Publisher
Current Science Inc.
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Authors: Jürgen Bohlender Jürg Nussberger Hans Imboden
Publish Date: 2012/11/30
Volume: 15, Issue: 1, Pages: 10-16
Abstract
Intrarenal neurotransmission implies the corelease of neuropeptides at the neuroeffector junction with direct influence on parameters of kidney function The presence of an angiotensin Ang IIcontaining phenotype in catecholaminergic postganglionic and sensory fibers of the kidney based on immunocytological investigations has only recently been reported These angiotensinergic fibers display a distinct morphology and intrarenal distribution suggesting anatomical and functional subspecialization linked to neuronal Ang IIexpression This review discusses the present knowledge concerning these fibers and their significance for renal physiology and the pathogenesis of hypertension in light of established mechanisms The data suggest a new role of Ang II as a cotransmitter stimulating renal target cells or modulating nerve traffic from or to the kidney Neuronal Ang II is likely to be an independent source of intrarenal Ang II Further physiological experimentation will have to explore the role of the angiotensinergic renal innervation and integrate it into existing concepts
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