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Title of Journal: Curr Hypertens Rep

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Abbravation: Current Hypertension Reports

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Current Science Inc.

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DOI

10.1002/art.1780400802

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1534-3111

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Sympathetic Hyperactivity in Chronic Kidney Diseas

Authors: Eva E Vink Rosa L de Jager Peter J Blankestijn
Publish Date: 2013/01/26
Volume: 15, Issue: 2, Pages: 95-101
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Abstract

Abundant evidence shows that chronic kidney disease CKD is a disease state characterized by increased sympathetic activation Kidney injury ischemia plays a central role in this pathogenesis Sympathetic excitation is associated with an increased risk of cardiovascular morbidity and mortality Several pharmacologic strategies are developed to decrease sympathetic activity However these medications have limitations Percutaneous catheterbased renal denervation has the potential to become a new treatment option for CKD This current report focuses on the effects of sympathetic hyperactivity in CKD and gives an overview in experimental as well as clinical evidence for a central role of the kidneys in the pathophysiology of sympathetic hyperactivity Moreover the effect of pharmacologic treatment and the potential beneficial effect of renal denervation will be discussed

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Other Papers In This Journal:
  1. Endothelin Antagonism and Its Role in the Treatment of Hypertension
  2. Neurogenic Hypertension: Revelations from Genome-Wide Gene Expression Profiling
  3. Angiotensin II and Vascular Injury
  4. Angiotensinergic Innervation of the Kidney: Present Knowledge and Its Significance
  5. Excess Cardiovascular Risk in Diabetic Women: A Case for Intensive Treatment
  6. Prehypertension: Risk stratification and management considerations
  7. Effects of Intrauterine Growth Restriction and Female Sex on Future Blood Pressure and Cardiovascular Disease
  8. Vasopressin Receptor Antagonists
  9. Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension
  10. The “His and Hers” of the Renin-Angiotensin System
  11. Mitochondrial Dysfunction and Oxidative Damage to Sarcomeric Proteins
  12. New aspects of the relationship among hypertension, obesity, and the kidneys
  13. Cerebrovascular Dysfunction in Preeclamptic Pregnancies
  14. Cell Signaling of Angiotensin II on Vascular Tone: Novel Mechanisms
  15. Secondary Hypertension in Pregnancy
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