Journal Title
Title of Journal: Curr Hypertens Rep
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Abbravation: Current Hypertension Reports
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Publisher
Current Science Inc.
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Authors: Aurelie Nguyen Dinh Cat Rhian M Touyz
Publish Date: 2011/01/29
Volume: 13, Issue: 2, Pages: 122-128
Abstract
Angiotensin II Ang II is a pleiotropic hormone that influences the function of many cell types and regulates many organ systems In the cardiovascular system it is a potent vasoconstrictor that increases peripheral vascular resistance and elevates arterial pressure It also promotes inflammation hypertrophy and fibrosis which are important in vascular remodeling in cardiovascular diseases The diverse actions of Ang II are mediated via AT1 and AT2 receptors which couple to many signaling molecules including small G proteins phospholipases mitogenactivated protein MAP kinases phosphatases tyrosine kinases NADPH oxidase and transcription factors In general acute Ang II stimulation induces vasoconstriction through changes in the intracellular free calcium concentration Ca2+i whereas longterm stimulation leads to cell proliferation and proinflammatory responses This review focuses on signaling processes of vasoconstriction and highlights some new mechanisms regulating the contractile machinery in controlling vasomotor tone by Ang II including RhoA/Rho kinase transient receptor potential TRP channels reactive oxygen species and arachidonic acid metabolites
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