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Title of Journal: Curr Hypertens Rep

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Abbravation: Current Hypertension Reports

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Current Science Inc.

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DOI

10.1007/bf01421374

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1534-3111

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The “His and Hers” of the ReninAngiotensin System

Authors: Lucinda M Hilliard Amanda K Sampson Russell D Brown Kate M Denton
Publish Date: 2012/11/21
Volume: 15, Issue: 1, Pages: 71-79
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Abstract

Sex differences exist in the regulation of arterial pressure and renal function by the reninangiotensin system RAS This may in part stem from a differential balance in the pressor and depressor arms of the RAS In males the ACE/AngII/AT1R pathways are enhanced whereas in females the balance is shifted towards the ACE2/Ang17/MasR and AT2R pathways Evidence clearly demonstrates that premenopausal women as compared to agedmatched men are protected from renal and cardiovascular disease and this differential balance of the RAS between the sexes likely contributes With aging this cardiovascular protection in women is lost and this may be related to loss of estrogen postmenopause but the possible contribution of other sex hormones needs to be further examined Restoration of these RAS depressor pathways in older women or upregulation of these in males represents a therapeutic target that is worth pursuing

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Other Papers In This Journal:
  1. Endothelin Antagonism and Its Role in the Treatment of Hypertension
  2. Neurogenic Hypertension: Revelations from Genome-Wide Gene Expression Profiling
  3. Angiotensin II and Vascular Injury
  4. Angiotensinergic Innervation of the Kidney: Present Knowledge and Its Significance
  5. Excess Cardiovascular Risk in Diabetic Women: A Case for Intensive Treatment
  6. Prehypertension: Risk stratification and management considerations
  7. Effects of Intrauterine Growth Restriction and Female Sex on Future Blood Pressure and Cardiovascular Disease
  8. Vasopressin Receptor Antagonists
  9. Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension
  10. Sympathetic Hyperactivity in Chronic Kidney Disease: Pathophysiology and (New) Treatment Options
  11. Mitochondrial Dysfunction and Oxidative Damage to Sarcomeric Proteins
  12. New aspects of the relationship among hypertension, obesity, and the kidneys
  13. Cerebrovascular Dysfunction in Preeclamptic Pregnancies
  14. Cell Signaling of Angiotensin II on Vascular Tone: Novel Mechanisms
  15. Secondary Hypertension in Pregnancy
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