Authors: Naoyuki Miyasaka Mihoko Akiyoshi Toshiro Kubota
Publish Date: 2013/11/08
Volume: 32, Issue: 5, Pages: 588-592
Abstract
The autonomic nervous system ANS has attracted attention as a regulator of bone remodeling and the effects of betablockers on the prevention of osteoporosis have been studied However results are as yet inconclusive and the physiological role of the ANS in bone metabolism has not been clarified Thus we investigated the relationship between bone mineral density BMD and ANS activity in nonmedicated perimenopausal women ANS activity was evaluated by power spectral analysis of heart rate variability and overall ANS activity and the balance between sympathetic and parasympathetic nervous activities SNS and PNS were quantified Pre and postmenopausal subjects were divided into higher or lower overall ANS activity groups and were also divided into SNS and PNSdominant groups BMD percentage of young adult mean was significantly higher in the higher overall ANS group than in the lower group 1122 ± 162 vs 997 ± 148 p 005 of premenopausal subjects but not in postmenopausal subjects 915 ± 159 vs 910 ± 149 BMD was significantly higher in the SNSdominant group than in the PNSdominant group 941 ± 163 vs 884 ± 188 p 005 of postmenopausal subjects but not in the premenopausal subjects 1035 ± 184 vs 1072 ± 146 Our study revealed that ANS influences bone metabolism under physiological conditions Thus it appears to be worthwhile to introduce ANS activity evaluation into the management of bone health in perimenopausal women
Keywords: