Authors: Baris Ozgur Donmez Mustafa Unal Semir Ozdemir Nihal Ozturk Nurettin Oguz Ozan Akkus
Publish Date: 2016/04/02
Volume: 35, Issue: 2, Pages: 161-170
Abstract
Inhibitors of the renin−angiotensin system used to treat several diseases have also been shown to be effective on bone tissue suggesting that angiotensinconverting enzyme inhibitors and angiotensin receptor blockers may reduce fracture risk The present study investigated the effects of losartan on the physicochemical and biomechanical properties of diabetic rat bone Losartan 5 mg/kg/day was administered via oral gavage for 12 weeks Bone mineral density BMD was measured using dualenergy Xray absorptiometry Whole femurs were tested under tension to evaluate the biomechanical properties of bone The physicochemical properties of bone were analyzed by Fourier transform infrared spectroscopy Although losartan did not recover decreases in the BMD of diabetic bone it recovered the physicochemical mineral and collagen matrix properties of diabetic rat bone Furthermore losartan also recovered ultimate tensile strength of diabetic rat femurs Losartan an angiotensin II type 1 receptor blocker has a therapeutic effect on the physicochemical properties of diabetic bone resulting in improvement of bone strength at the material level Therefore specific inhibition of this pathway at the receptor level shows potential as a therapeutic target for diabetic patients suffering from bone diseases such as osteopenia
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