Authors: Shinichi Nakatoh
Publish Date: 2017/03/14
Volume: 36, Issue: 2, Pages: 221-228
Abstract
This study reveals the changes in bone mineral density BMD the turnover rate and the balance multiple of median formation/multiple of median resorption MoMf/MoMr affected by the selection of different bone resorption inhibitors after 24month daily teriparatide 20 µg/day administration The turnover rate was calculated as √MoMf2 + MoMr2 where MoMf = bonespecific alkaline phosphatase BAP value/186 and MoMr = tartrateresistant acid phosphatase 5b TRACP5b value/463 One hundred and twentyone osteoporotic women mean age 824 years were randomly administered minodronate 50 mg/28 days raloxifene 60 mg/day or eldecalcitol 075 µg/day after teriparatide discontinuation BMD was measured at 0 24 and 48 weeks BAP values and TRACP5b were measured at 0 12 24 36 and 48 weeks after administration of bone resorption inhibitors In the minodronate group BMD increased significantly from week 0 to weeks 24 and 48 The turnover rate was significantly reduced at week 12 and remained so over the entire course in all three groups The speed of change of turnover rate was greatest in the minodronate group The balance in the minodronate group shifted significantly toward formation dominance at week 12 to 097 from 087 and then again toward resorption dominance to 084 at week 24 However no further advancement in resorption dominance was observed until week 48 Conversely the balance in the raloxifene and eldecalcitol groups shifted toward resorption dominance gradually over the entire course In conclusion the BMDincreasing effect was greatest with minodronate administration and depends not only on the decrease in turnover rate but also on changes in balance after teriparatide discontinuation
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