Fabrication and evaluation of growth factorimmobi

Authors: Jun Goo Kang Tae Ho Kim Se Heang Oh Jin Ho Lee

Publish Date: 2014/02/26

Volume: 11, Issue: 1, Pages: 8-15

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Abstract

Growth factor basic fibroblast growth factor bFGF or epidermal growth factor EGFimmobilized polycaprolactone PCL/Pluronic F127 microspheres were fabricated to investigate their potential use as an injectable bioactive filler for enhancing soft tissue augmentation It was expected that the microspheres may stimulate the regeneration of soft tissues by the sustained release of the growth factors as well as provide a bulking effect by the injected volume of the microspheres and thus allow more effective longterm filling effect The PCL/F127 microspheres were fabricated by an isolated particlemelting method and the growth factors were easily immobilized onto the surfaces of the PCL/F127 microspheres via heparin binding From an in vivo animal study it was observed that the mixture of both bFGFimmobilized and EGFimmobilized microspheres lead to effective soft tissue augmentation

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