Journal Title
Title of Journal: Tissue Eng Regen Med
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Abbravation: Tissue Engineering and Regenerative Medicine
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Publisher
Korean Tissue Engineering and Regenerative Medicine Society
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Authors: GuangYin Shen InHwa Park YiSun Song HyunWoo Joo Yonggu Lee JeongHun Shin KyungSoo Kim Hyuck Kim
Publish Date: 2016/06/09
Volume: 13, Issue: 3, Pages: 297-303
Abstract
A systemic treatment of granulocytecolony stimulating factor GCSF is known to improve healings of damaged tissues However recent studies suggested local actions of GCSF on the healing processes of damaged tissues We investigated the treatment effect of locally injected GCSF and compared to that of systemically injected GCSF in a rat model A wound was created on the rat dorsum and treated either by local injection or by systemic injection of GCSF Wound healing rate deposition of collagen and gene expression were evaluated GCSF receptor GCSFR protein was detected by Western blotting The wound healing rate in the local injection group was significantly higher than that in the systemic injection group at days 9 and 15 it was also significantly higher than that in the control group at days 3 9 and 15 The expression of GCSFR protein in wound tissues was higher than in normal skin tissues The local injection of GCSF is more effective than systemic injection of GCSF in promoting wound healing which may implicate the local action of GCSF treatment in wound healing processes
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