LowLevel Laser Irradiation Improves Motor Recover

Authors: Junesun Kim EunHye Kim Koeun Lee Bokkyu Kim Youngkyung Kim Sook Hyun Na Young Wook Yoon

Publish Date: 2017/01/17

Volume: 14, Issue: 1, Pages: 57-64

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Abstract

This study investigated the therapeutic effects of lowlevel laser irradiation LLLI on the recovery of motor function and its underlying mechanisms in rats with spinal cord injury SCI The spinal cord was contused at the T11 level using a New York University impactor Thirtyeight rats were randomly divided into four groups LLLI with 008 J 04 J 08 J and sham We transcutaneously applied at the lesion site of the spinal contusive rats 5 min after injury and then daily for 21 days The Basso Beattie and Bresnahan BBB locomotor scale and combined behavioral score CBS were used to evaluate motor function The spinal segments of rostral and caudal from the lesion site the epicenter and L4–5 were collected from normal and the all groups at 7 days after SCI The expression of tumor necrosis factorα TNFα and inducible nitric oxide synthase iNOS was compared across groups in all regions In the present study LLLI with 04 J and 08 J led to a significant improvement in motor function compared to sham LLLI which significantly decreased TNFα expression at the lesion epicenter and reduced iNOS expression in the caudal segment for all LLLI groups and in the L4–5 segments for the 04 J and 08 J groups when compared to sham LLLI group Our results demonstrate that transcutaneous LLLI modulate inflammatory mediators to enhance motor function recovery after SCI Thus LLLI in acute phase after SCI might have therapeutic potential for neuroprotection and restoration of motor function following SCIThis work was supported by the convergence technology development program for bionic arm and by the Basic Science Research Program through the National Research Foundation of Korea NRF funded by the Ministry of Science ICT Future Planning 2014M3C1B2048632 and by the Ministry of Education 2016R1D1A1B03933986 It was also partially supported by a grant of the Korea University College of Health Science K1508371

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