Authors: Kenichi Murai Yutaka Tazawa Masaki Kobayashi Akira Hayasaka
Publish Date: 2004/05/01
Volume: 48, Issue: 3, Pages: 215-221
Abstract
Twenty patients 20 eyes with glaucomaages 46 to 69 years were studied Twenty healthy volunteers 20 eyes with normal intraocular pressure and with no eye diseases served as controls The retinal sensitivities of the upper and lower visual fields of the glaucomatous eyes were determined with a Humphrey Field Analyzer The severity of retinal sensitivity depression was rated as mild Group A intermediate Group B or severe Group C To record the swave mfERGs were elicited by pseudorandom stimulation with the stimulus alternating according to a binary msequence for base periods bpds of 133 267 533 1067 and 2133 ms The mfERGwaves recorded from the upper and lower visual field were summed separatelyIn the control group the swave in the summed mfERG was observed in all visual field halves at all bpds 533 ms or longer The swave amplitude at a bpd of 2133 ms was significantly larger than that at a bpd of 533 ms P 005 The swave was also present in the glaucoma patients’ eyes and the swave amplitude increased as the bpd increased At bpds of 533 1067 and 2133ms the mean swave amplitudes in Groups B and C were significantly smaller than those in the control group P 005 001 and 005 respectively At bpds of 533 and 1067 ms the mean amplitude of the swaves in Group C was significantly smaller than that in Group A P 005 At a bpd of 1067 ms a significant correlation was observed between the retinal sensitivity and the swave amplitude P 005The significant correlation between the retinal sensitivity and the amplitude of the swave at a bpd of 1067 ms supports the suggestion that the swave originates from the retinal ganglion cells and their axons The amplitude of the swave may serve as an objective indicator of the severity of retinal ganglion cell damage
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