Authors: Masahiro Orihashi Yuichiro Shima Hiroshi Tsuneki Ikuko Kimura
Publish Date: 2005/11/01
Volume: 49, Issue: 6, Pages: 523-526
Abstract
Nipradilol 025 timolol 05 and bunazosin 001 individually lowered IOP The IOPlowering effects of both nipradilol and timolol were significantly enhanced by the combined application of bunazosin 001 In the presence of 5 timolol or 01 bunazosin IOP was further lowered by the addition of nipradilol The IOPlowering effect of nipradilol was partly inhibited by pretreatment with cPTIO 10 mM a nitric oxide NOtrapping agentThe present study demonstrated that the IOPlowering effects of nipradilol are due to β and α1blocking and NOdonating actions and bunazosin has an additive effect on the IOPlowering effect of nipradilol or timolol Jpn J Ophthalmol 200549523–526 © Japanese Ophthalmological Society 2005
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