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Title of Journal: Jpn J Ophthalmol

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Abbravation: Japanese Journal of Ophthalmology

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Springer Japan

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DOI

10.1016/0012-365x(82)90024-3

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ISSN

1613-2246

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The Inhibitory Effect of Aldose Reductase Inhibito

Authors: Soichi Morikubo Yoshihiro Takamura Eri Kubo Shosai Tsuzuki Yoshio Akagi
Publish Date: 2016/02/10
Volume: 48, Issue: 2, Pages: 185-185
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Abstract

SpragueDawley rats were fed a diet containing 50 galactose with or without ARI SNK860 Histological changes in the lenses were observed by light microscopy and the amount of galactitol accumulated in the lens epithelium was measured by liquidgas chromatography Immunohistochemical staining of proliferating cell nuclear antigen PCNA in wholemount preparations was performed to assay the proliferative ability of the lens epithelial cellsThe amount of galactitol in the lens epithelium and the number of PCNA positive cells in rats administered ARI were less than in rats fed the galactose diet Multilayered epithelium was observed in advanced cataract of rats fed the galactose diet but not in the rats given ARI

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  2. Bilateral cataract surgery: A controlled clinical trial
  3. Changes in dry eye diagnostic status following implementation of revised Japanese dry eye diagnostic criteria
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