Authors: Sei Yamazaki Mami Nanno Tairo Kimura Hirotaka Suzumura Keiji Yoshikawa
Publish Date: 2010/02/12
Volume: 54, Issue: 1, Pages: 7-14
Abstract
Patients with either primary openangle glaucoma or ocular hypertension treated with LAT for at least 1 month who presented with SPK participated in this prospective multicenter openlabel uncontrolled study After the switch from LAT to TRV patients were monitored at 2 weeks and at 1 2 and 3 months The use of concomitantly employed ophthalmic solutions was continued during the observation period The intensity of SPK in each of five areas defined on the cornea was scored on a standard scale Repeated measurements were tested with a linear mixed modelOf the 48 patients enrolled 45 patients completed the study After the switch to TRV the mean SPK score in the whole cornea decreased significantly at every observation point P 00001 at each point while intraocular pressure did not change significantly Throughout the observation period the SPK score tended to be higher in patients using a larger number of concomitant medications that contained BAC
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