Authors: Keiji Yoshikawa Harumi Katsushima Tairo Kimura Kazuya Yamagishi Shigeki Yamabayashi
Publish Date: 2006/09/01
Volume: 50, Issue: 5, Pages: 443-448
Abstract
Bunazosin was administered to NTG patients aged 65 years or over who had been undergoing topical glaucoma therapy In accordance with the study protocol intraocular pressure IOP and visual field measurement were performed and the safety of the treatment was evaluated periodically between week 0 and week 52 at the five facilities where the study was carried outOf the 98 enrolled patients 84 857 were followed up for 52 weeks During the followup period IOP significantly and persistently decreased week 0 150 ± 25 mmHg week 52 134 ± 24 mmHg P 00001 but the decrease in mean deviation MD was not significant Although no systemic adverse reactions were observed local adverse events were noted in 7 of the 98 patientsThe addition of or the switch to bunazosin in elderly NTG patients resulted in a significant reduction of IOP without apparent exacerbation of visual field defects or systemic or local adverse reactions other than conjunctival hyperemia Jpn J Ophthalmol 200650443–448 © Japanese Ophthalmological Society 2006
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