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Title of Journal: Jpn J Ophthalmol

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Abbravation: Japanese Journal of Ophthalmology

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Springer Japan

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DOI

10.1016/0921-4534(89)90807-1

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1613-2246

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Current status of antivascular endothelial growth

Authors: Sebastian Wolf
Publish Date: 2008/11/01
Volume: 52, Issue: 6, Pages: 433-439
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Abstract

Vascular endothelial growth factor VEGF is an important modulator of angiogenesis and has been implicated in the pathology of a number of conditions including agerelated macular degeneration AMD diabetic retinopathy and cancer AMD is a progressive disease of the macula and the third major cause of blindness worldwide If not treated appropriately AMD can progress rapidly causing legal blindness within months of the second eye becoming affected Until recently the treatment options for AMD have been limited with photodynamic therapy PDT the mainstay treatment Although PDT is effective at slowing disease progression it rarely results in improved vision Pegaptanib and ranibizumab are both antiVEGF therapies licensed for the treatment of neovascular AMD in Europe however these drugs are not yet available in Japan This article reviews the available clinical data on antiVEGF therapies for the treatment of neovascular AMD in Europe and considers the future of this exciting therapy

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Other Papers In This Journal:
  1. Validation of international criteria for the diagnosis of ocular sarcoidosis proposed by the first international workshop on ocular sarcoidosis
  2. Bilateral cataract surgery: A controlled clinical trial
  3. Changes in dry eye diagnostic status following implementation of revised Japanese dry eye diagnostic criteria
  4. Changes in dry eye diagnostic status following implementation of revised Japanese dry eye diagnostic criteria
  5. The Inhibitory Effect of Aldose Reductase Inhibitor on Proliferation in the Lens Epithelial Cells of Rat Sugar Cataract
  6. Retinal pigment epithelium atrophy secondary to dilated choroidal artery in the macula of a highly myopic patient
  7. An Asian Patient with Intraocular Lymphoma Treated by Intravitreal Methotrexate
  8. Diagnosis of uveal malignant melanoma by a new semiquantitative assessment of N -isopropyl- p -[ 123 I]-iodoamphetamine
  9. Lamellar macular hole formation in chronic cystoid macular edema associated with retinal vein occlusion
  10. Changes in morphology and visual function over time in mouse models of retinal degeneration: an SD-OCT, histology, and electroretinography study
  11. Measurements of transmission spectrums and estimation of retinal blue-light irradiance values of currently available clear and yellow-tinted intraocular lenses
  12. Effect and Mechanism of Betaxolol and Timolol on Vascular Relaxation in Isolated Rabbit Ciliary Artery
  13. Effects of switching to SofZia-preserved travoprost in patients who presented with superficial punctate keratopathy while under treatment with latanoprost
  14. Herpes Simplex Keratitis after Ophthalmic Surgery
  15. Retreatment of polypoidal choroidal vasculopathy after photodynamic therapy combined with intravitreal ranibizumab
  16. Visual acuity following intravitreal bevacizumab for macular edema associated with retinal vein occlusion
  17. Addition of or Switch to Topical Bunazosin Hydrochloride in Elderly Patients with Normal-Tension Glaucoma: A One-Year Follow-up Study
  18. Bilateral transient myopia, angle-closure glaucoma, and choroidal detachment induced by methazolamide
  19. Amplitude of the s-Wave of Multifocal Electroretinograms Can Indicate Local Retinal Sensitivity in Glaucomatous Eyes
  20. A survey of the surgical treatment of congenital and developmental cataracts in Japan
  21. Comparison of the intraocular pressure-lowering effect and safety of brimonidine/timolol fixed combination and 0.5 % timolol in normal-tension glaucoma patients
  22. OPA1 mutations in Japanese patients suspected to have autosomal dominant optic atrophy
  23. Noncompliance with glaucoma medication in Korean patients: a multicenter qualitative study
  24. Idiopathic macular hole vitrectomy without postoperative face-down positioning
  25. Association of contact lens-related allergic conjunctivitis with changes in the morphology of meibomian glands
  26. Indocyanine Green Angiography in a Case of Punctate Inner Choroidopathy Associated with Acute Zonal Occult Outer Retinopathy
  27. Characteristics of successful filtering blebs at 1 year after trabeculectomy using swept-source three-dimensional anterior segment optical coherence tomography
  28. Comparative Study on the Combined Effects of Bunazosin and Nipradilol or Timolol on Intraocular Pressure in Normotensive Rabbits
  29. Estimation of heritability in myopic twin studies
  30. Photodynamic therapy for polypoidal choroidal vasculopathy: Baseline perimetric results and visual outcomes
  31. Vitreous anatomy and the vitreomacular correlation
  32. Central thickening of the donor posterior corneal disc in femtosecond-laser-assisted Descemet’s stripping endothelial keratoplasty
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