Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Mol Imaging Biol

Search In Journal Title:

Abbravation: Molecular Imaging and Biology

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1016/0098-1354(89)85010-0

Search In DOI:

ISSN

1860-2002

Search In ISSN:
Search In Title Of Papers:

Comparison of Molecular Markers of Hypoxia and Ima

Authors: Perry W Grigsby Robert S Malyapa Ryuji Higashikubo Julie K Schwarz Michael J Welch Phyllis C Huettner Farrokh Dehdashti
Publish Date: 2007/04/13
Volume: 9, Issue: 5, Pages: 278-
PDF Link

Abstract

Fifteen patients were enrolled in a prospective study and underwent evaluation of tumor hypoxia with positron emission tomography PET using 60CuATSM 60CuATSMPET imaging was compared with the expression of tissue molecular markers which included vascular endothelial growth factor VEGF cyclooxygenase2 COX2 epidermal growth factor receptor EGFR carbonic anyhdrase IX CA9 and apoptotic indexSix patients had hypoxic tumors determined by 60CuATSM and nine had nonhypoxic tumors The 4year overall survival estimates were 75 for patients with nonhypoxic tumors and 33 for those with hypoxic tumors p = 004 Overexpression of VEGF p = 013 EGFR p = 005 CA9 p = 002 COX2 p = 008 and the presence of apoptosis p = 0005 occurred in patients with hypoxic tumors Cox proportional hazards modeling demonstrated hypoxia as determined by 60CuATSM to be a significant independent predictor of tumor recurrence p = 00287

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. In Vitro and In Vivo Structure–Property Relationship of 68 Ga-Labeled Schiff Base Derivatives for Functional Myocardial PET Imaging
  2. Imaging of Cholinergic and Monoaminergic Neurochemical Changes in Neurodegenerative Disorders
  3. Initial Comparison of ntPET with Microdialysis Measurements of Methamphetamine-Induced Dopamine Release in Rats: Support for Estimation of Dopamine Curves from PET Data
  4. Dynamic Changes of FDG Uptake and Clearance in Normal Tissues
  5. 700-nm Zwitterionic Near-Infrared Fluorophores for Dual-Channel Image-Guided Surgery
  6. Clinical Value of Image Fusion from MR and PET in Patients with Head and Neck Cancer
  7. Association of the VEGF 936C>T Polymorphism with FDG Uptake, Clinical, Histopathological, and Metabolic Response in Patients with Adenocarcinomas of the Esophagogastric Junction
  8. The Relationship between Patients’ Serum Glucose Levels and Metabolically Active Brown Adipose Tissue Detected by PET/CT
  9. First Evaluation of [ 11 C]R116301 as an In Vivo Tracer of NK1 Receptors in Man
  10. Total Choline at 1H-MRS and [18F]-Fluoromethylcholine Uptake at PET
  11. Imaging and Pharmacokinetics of 64 Cu-DOTA-HB22.7 Administered by Intravenous, Intraperitoneal, or Subcutaneous Injection to Mice Bearing Non-Hodgkin’s Lymphoma Xenografts
  12. Assessment of Molecular Acoustic Angiography for Combined Microvascular and Molecular Imaging in Preclinical Tumor Models
  13. Qualitative and Quantitative Evaluation of Blob-Based Time-of-Flight PET Image Reconstruction in Hybrid Brain PET/MR Imaging
  14. Improved Radiosynthesis and Biological Evaluations of L- and D-1-[ 18 F]Fluoroethyl-Tryptophan for PET Imaging of IDO-Mediated Kynurenine Pathway of Tryptophan Metabolism
  15. In Vivo MR Imaging of Fibrin in a Neuroblastoma Tumor Model by Means of a Targeting Gd-Containing Peptide
  16. “Magnetic Resonance Imaging Negative Positron Emission Tomography Positive” Temporal Lobe Epilepsy: FDG-PET Pattern Differs from Mesial Temporal Lobe Epilepsy
  17. NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of FLT as a Marker of Proliferation in Patients with Recurrent Gliomas: Safety Studies
  18. Towards a Successful Clinical Implementation of Fluorescence-Guided Surgery
  19. Comparison of [ 11 C]Choline ([ 11 C]CHO) and [ 18 F]Bombesin (BAY 86-4367) as Imaging Probes for Prostate Cancer in a PC-3 Prostate Cancer Xenograft Model
  20. Half-Time SPECT Acquisition with Resolution Recovery for Tc-MIBI SPECT Imaging in the Assessment of Hyperparathyroidism
Search Result: