Authors: Alexander M Spence Mark Muzi Jeanne M Link John M Hoffman Janet F Eary Kenneth A Krohn
Publish Date: 2008/06/10
Volume: 10, Issue: 5, Pages: 271-280
Abstract
3’F18Fluoro3’deoxythymidine FLT is an analog of thymidine that is being developed for imaging cellular proliferation The goal of this study was to prove that the dose of FLT used for positron emission tomography imaging produces no significant toxicityTwelve patients with gliomas with either recurrence or suspected radionecrosis were imaged with FLT Before and at several time points after imaging subjects underwent general physical and neurological examinations with review of systems and tests of hematologic hepatic renal and several other metabolic parameters Vital signs and electrocardiograms were monitored during and after the imaging sessionThere were no significant adverse effects from FLT injected at a dose of 007 mCi/kg maximum of 5 mCi at specific activities of 125 Ci/μmol or higher The FLT mass administered for imaging was 00001 to 00009 of the least toxic cumulative dose administered in clinical trials of FLT as an antiretroviral agentLalitha K Shankar MD PhD and Paula M Jacobs PhD are gratefully acknowledged for their indispensable help with the contracts and the statistical analyses This study was supported by National Cancer Institute Contract N01CM37008 Subcontract NCI CIP/SAIC BOA 24XS036 and S10 RR17229
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