Journal Title
Title of Journal: Mol Imaging Biol
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Abbravation: Molecular Imaging and Biology
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Authors: Sarah Marie Schwarzenböck Philipp Schmeja Jens Kurth Michael Souvatzoglou Roman Nawroth Uwe Treiber Guenther Kundt Sandra Berndt Keith Graham Reingard SenekowitschSchmidtke Markus Schwaiger Sibylle I Ziegler Ludger Dinkelborg HansJürgen Wester Bernd Joachim Krause
Publish Date: 2015/10/19
Volume: 18, Issue: 3, Pages: 393-401
Abstract
Carbon11 and fluorine18labeled choline derivatives are commonly used in prostate cancer imaging in the clinical setting for staging and restaging of prostate cancer Due to a limited detection rate of established positron emission tomography PET tracers there is a clinical need for innovative tumorspecific PET compounds addressing new imaging targets The aim of this study was to compare the properties of 18FBombesin BAY 864367 as an innovative biomarker for prostate cancer imaging targeting the gastrinreleasing peptide receptor and 11CCholine 11CCHO in a human prostate tumor mouse xenograft model by small animal PET/Xray computed tomography CTWe carried out a dualtracer small animal PET/CT study comparing 18FBombesin and 11CCHO The androgenindependent human prostate tumor cell line PC3 was implanted subcutaneously in the flanks of nu/nu NMRI mice n = 10 PET/CT measurements of two 11CCholine mice could not be analyzed due to technical reasons 18FBombesin and 11CCHO PET/CT imaging was performed about 3–4 weeks after the implantation of PC3 cells on two separate days After the intravenous tail vein injection of 14 MBq 18FBombesin and 37 MBq 11CCHO respectively a dynamic study over 60 min was acquired in list mode using an Inveon animal PET/CT scanner Siemens Medical Solutions The sequence of 18FBombesin and 11CCHO was randomized Image analysis was performed using summed images as well as dynamic data To calculate static and dynamic tumortomuscle T/M tumortoblood T/B livertoblood L/B and kidneytoblood K/B ratios 4 × 4 × 4 mm3 volumes of interest VOIs of tumor muscle thigh liver kidney and blood derived from transversal slices were usedThe mean T/M ratio of 18FBombesin and 11CCHO was 654 ± 249 and 135 ± 030 respectively The mean T/B ratio was 183 ± 079 for 18FBombesin and 055 ± 010 for 11CCHO The T/M ratio as well as the T/B ratio for 18FBombesin were significantly higher compared to those for 11CCHO p 0001 respectively Kidney and liver uptake was statistically significantly lower for 18FBombesin K/B 341 ± 081 L/B 199 ± 038 compared to 11CCHO K/B 791 ± 185 p 0001 L/B 627 ± 199 p 0001 The magnitudes of the time course of T/M and T/B ratios T/M and T/Bdyn ratios were statistically significantly different showing a higher uptake of 18FBombesin compared to 11CCHO additionally also the change of the T/M and T/B ratios over time was significantly different between both tracers in the dynamic analysis p 0001 respectively Furthermore there was a statistically significantly different change of the K/B and L/B ratios over time between the two tracers in the dynamic analysis p = 0026 and p 0001 respectively18FBombesin BAY 864367 visually and semiquantitatively outperforms 11CCHO in the PC3 prostate cancer xenograft model 18FBombesin tumor uptake was significantly higher compared to 11CCHO 18FBombesin showed better imaging properties compared to the clinically utilized 11CCHO due to a higher tumor uptake as well as a lower liver and kidney uptake
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