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Title of Journal: Mol Imaging Biol

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Abbravation: Molecular Imaging and Biology

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Springer-Verlag

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DOI

10.1016/j.apmr.2015.05.012

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1860-2002

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Imaging of Cholinergic and Monoaminergic Neurochem

Authors: Nicolaas I Bohnen Kirk A Frey
Publish Date: 2007/02/21
Volume: 9, Issue: 4, Pages: 243-257
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Abstract

Positron emission tomography PET or single photon emission computer tomography SPECT imaging provides the means to study neurochemical processes in vivo These methods have been applied to examine monoaminergic and cholinergic changes in neurodegenerative disorders These investigations have provided important insights into disorders such as Alzheimer’s disease AD and Parkinson’s disease PD The most intensely studied monoaminergic transmitter is dopamine The extent of presynaptic nigrostriatal dopaminergic denervation can be quantified in PD and may serve as a diagnostic biomarker Dopaminergic receptor imaging may help to distinguish idiopathic PD from atypical parkinsonian disorders Cholinergic denervation has been identified not only in AD but also in PD and more severely in parkinsonian dementia PET or SPECT can also provide biomarkers to follow progression of disease or evaluate the effects of therapeutic interventions Cholinergic receptor imaging is expected to play a major role in new drug development for dementing disorders

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  1. In Vitro and In Vivo Structure–Property Relationship of 68 Ga-Labeled Schiff Base Derivatives for Functional Myocardial PET Imaging
  2. Initial Comparison of ntPET with Microdialysis Measurements of Methamphetamine-Induced Dopamine Release in Rats: Support for Estimation of Dopamine Curves from PET Data
  3. Dynamic Changes of FDG Uptake and Clearance in Normal Tissues
  4. 700-nm Zwitterionic Near-Infrared Fluorophores for Dual-Channel Image-Guided Surgery
  5. Comparison of Molecular Markers of Hypoxia and Imaging with 60 Cu-ATSM in Cancer of the Uterine Cervix
  6. Clinical Value of Image Fusion from MR and PET in Patients with Head and Neck Cancer
  7. Association of the VEGF 936C>T Polymorphism with FDG Uptake, Clinical, Histopathological, and Metabolic Response in Patients with Adenocarcinomas of the Esophagogastric Junction
  8. The Relationship between Patients’ Serum Glucose Levels and Metabolically Active Brown Adipose Tissue Detected by PET/CT
  9. First Evaluation of [ 11 C]R116301 as an In Vivo Tracer of NK1 Receptors in Man
  10. Total Choline at 1H-MRS and [18F]-Fluoromethylcholine Uptake at PET
  11. Imaging and Pharmacokinetics of 64 Cu-DOTA-HB22.7 Administered by Intravenous, Intraperitoneal, or Subcutaneous Injection to Mice Bearing Non-Hodgkin’s Lymphoma Xenografts
  12. Assessment of Molecular Acoustic Angiography for Combined Microvascular and Molecular Imaging in Preclinical Tumor Models
  13. Qualitative and Quantitative Evaluation of Blob-Based Time-of-Flight PET Image Reconstruction in Hybrid Brain PET/MR Imaging
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  15. In Vivo MR Imaging of Fibrin in a Neuroblastoma Tumor Model by Means of a Targeting Gd-Containing Peptide
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  17. NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of FLT as a Marker of Proliferation in Patients with Recurrent Gliomas: Safety Studies
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