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Title of Journal: In Vitro CellDevBiolAnimal

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Abbravation: In Vitro Cellular & Developmental Biology - Animal

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Springer-Verlag

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DOI

10.1002/jhet.5570030304

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1543-706X

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Neoplastic transformation and induction of HSuper

Authors: Osamu Shimokawa Hirofumi Matsui Yumiko Nagano Tsuyoshi Kaneko Takeshi Shibahara Akira Nakahara Ichinosuke Hyodo Akinori Yanaka Hideyuki J Majima Yukio Nakamura Yasushi Matsuzaki
Publish Date: 2007/11/22
Volume: 44, Issue: 1-2, Pages: 26-30
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Abstract

NmethylN′nitroNnitrosoguanidine MNNG induces gastric cancer in animal models We established an MNNGinduced mutant of the rat murine RGM1 gastric epithelial cell line which we named RGK1 that could be used as an in vitro model of gastric cancer This cell line showed signs of neoplasia and transformation in that it lost contact inhibition and formed tumors in nude mice The mutant cells also expressed parietal cellspecific H+K+adenosine triphosphatase H+K+ATPase which parent RGM1 did not The results suggested that parent RGM1 cells were gastric progenitor cells This mutant RGK1 cell line will contribute to future investigation on gastric carcinogenesis and to the development of other pathophysiologic fieldsWe thank Dr Tsuyoshi Hayakawa Dr Kenichi Hirano and Dr Atsunori Tsuji from Hamamatsu Photonics for their continuous support and critical review of the manuscript We also thank Dr Mutsumi Muramatsu Ms Rui Maeda and Ms Junko Sakamoto for experimental support

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