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Title of Journal: In Vitro CellDevBiolAnimal

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Abbravation: In Vitro Cellular & Developmental Biology - Animal

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Springer US

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10.1016/0022-0248(93)90737-h

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1543-706X

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Transcriptome analysis reveals the potential mecha

Authors: Wu Jin Haibo Wen Xingwei Du Jinliang Zheng Ruobo Gu
Publish Date: 2015/03/12
Volume: 51, Issue: 6, Pages: 572-577
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Abstract

Our aim was to explore the potential mechanism underlying albino in Takifugu obscurus The transcriptome sequencing of the skin samples from normal T obscurus and albino ones was conducted in this paper The differentially expressed genes DEGs in albino fish compared with controls were assayed The gene ontology GO and Kyoto encyclopedia of genes and genomes KEGG pathway analysis were performed to explore the differentially expressed gene DEGrelated functions and pathways A total of 32 genes were found to be differentially expressed including eight upregulated ones and 24 downregulated ones Five GO terms were significantly enriched such as hemoglobin complex and oxygen transporter activity The significantly enriched pathways contained linoleic acid metabolism and arachidonic acid metabolism Hemoglobin complex linoleic and arachidonic acid metabolism may dysregulated in albino fugu Dietary control of the linoleic acid and arachidonic acid may be an effective management for mediating albino in T obscurusThis work was supported by the National Nonprofit Institute Research Grant of Freshwater Fisheries Research Center CAFS 2013JBFR07 We wish to express our warm thanks to Fenghe Shanghai Information Technology Co Ltd Their ideas and help gave a valuable added dimension to our research

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