Authors: Miguel Sáenz de Pipaón Marcos Juan Rodríguez Delgado Miriam Martínez Biarge Jesús Pérez Rodríguez Grevelyn Sosa Rotundo Juan A Tovar Larrucea José Quero Jiménez
Publish Date: 2008/05/06
Volume: 24, Issue: 7, Pages: 831-835
Abstract
The aim of this study was to correlate the clinical course of necrotizing enterocolitis NEC with infection by coagulasenegative Staphylococcus at the onset of the illness Records of all newborn infants developing NEC between January 1998 and December 2001 were reviewed NEC was classified according to the criteria of Bell et al Numeric variables were described by standard statistical methods Comparisons between subgroups were performed by parametric statistical tests Fortyfour patients developed NEC stage II n = 25 or III n = 19 The incidence was 0024 of live births in the hospital and the mortality rate was 9 The main risk factor was prematurity 84 Only onefourth of the patients had gastric residuals A platelet count of 100000 cells/mm3 occurred only in grade III NEC Blood cultures were positive in 34 of the patients The predominant organism 73 was coagulasenegative Staphylococcus CoNS Neither Clostridium nor Bacteroides species were isolated Stage II patients were maintained nothing per os NPO for 9 ± 3 days and received antibiotics for 10 ± 3 days All of the stage III patients required an operation In onethird of them primary peritoneal drainage was initially performed but all required further operative procedures We report a low incidence and mortality rate of necrotizing enterocolitis Thrombocytopenia is confirmed as a marker of severity Positive blood cultures for CoNS may explain at least in part the low mortality reported
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