Authors: Gong Chen Shan Zheng Xian Min Xiao Yi Luo
Publish Date: 2009/06/13
Volume: 25, Issue: 7, Pages: 635-640
Abstract
A total of 30 pregnant rabbits received fetal surgery on gestational day 23 A left diaphragmatic hernia was created in one end fetus DH group of each rabbit and the other end fetus of the same rabbit received sham thoracotomy as control CR group Another 19 pregnant rabbits underwent partial resection of the diaphragm in both end fetuses on gestational day 23 and then artificial gastroschisis was performed on one end fetus GS group on gestational day 26 while the other end remained as control CGS group The fetuses were harvested on gestational day 30 The histological and morphometric evaluation of lungs and livers of the end fetuses in each group was conductedIn the DH group the lungs were hypoplastic with a decrease in the total lung weight to body weight ratio and remarkable thickening in alveolar septa The lung vessels showed significantly thicker arterial walls when compared with those from control fetuses The pathological finding in the CGS group was similar to that of the DH group The thickness of the alveolar septa and of the pulmonary arterial walls showed no significant difference among the GS group DH group and the CGS group The ratio of liver weight to body weight increased notably in the GS group DH group and CGS group compared with that in the CR group
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