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Title of Journal: Pediatr Surg Int

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Abbravation: Pediatric Surgery International

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Springer Berlin Heidelberg

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DOI

10.1016/0043-1648(81)90043-0

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1437-9813

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Beneficial effects of Etanercept on experimental n

Authors: Sadık Yurttutan Ramazan Ozdemir Fuat Emre Canpolat Mehmet Yekta Oncel Hatice Germen Unverdi Bülent Uysal Ömer Erdeve Ugur Dilmen
Publish Date: 2013/09/27
Volume: 30, Issue: 1, Pages: 71-77
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Abstract

Tissue damage in necrotizing enterocolitis NEC of infants occurs as a result of an uncontrolled inflammatory response The aim of this study was to investigate any potential antiinflammatory effects that Etanercept may have on the inflammatory response in an experimental NEC model in newborn ratsNewborn pups were randomized into three groups immediately after birth Control NEC + Placebo and NEC + Etanercept Pups in the NEC + Placebo and NEC + Etanercept groups were subjected to an NECinducing protocol hypercarbia hypothermia and hyperoxia twice a day for 3 days Pups in the NEC + Etanercept group were given an intraperitoneal injection of Etanercept Rats were harvested for biochemical and histopathological examinationsThe histopathological injury score of rats in the NEC + Placebo group was significantly higher compared to the NEC + Etanercept and Control groups p  005 for both comparisons Tissue levels of tumor necrosis factorα interleukin1β and malondialdehyde were higher in the placebo group compared to the Etanercept group

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