Authors: Tetsuro Shirasaka Tatsuma Iwasaki Nobuko Hosokawa Miki Komatsu Toshiharu Kasaba Mayumi Takasaki
Publish Date: 2008/08/07
Volume: 22, Issue: 3, Pages: 322-
Abstract
The objective of this study was to investigate the effect of landiolol on the cardiovascular responses to emergence from anesthesia and tracheal extubation Fiftynine patients without cardiovascular disorders who were scheduled for tympanoplasty were randomly allocated to receive a loading dose of landiolol at 0125 mg·kg−1·min−1 for 1 min followed by an infusion at 001 mg·kg−1·min−1 group L1 002 mg·kg−1·min−1 group L2 003 mg·kg−1·min−1 group L3 or 004 mg·kg−1·min−1 group L4 At the end of surgery sevoflurane and nitrous oxide were discontinued and landiolol was started The mean arterial pressure MAP heart rate HR and rate pressure product RPP in the four groups were compared before anesthesia induction just after extubation 5 min after extubation 10 min after extubation and at discharge from the operating room Just after extubation compared with the baseline the MAP increased significantly in all groups the HR increased in groups L1 and L2 and the RPP increased in all groups except for group L4 Continuous administration of landiolol at 003 or 004 mg·kg−1·min−1 may prevent the increases in HR and RPP respectively that occur at the emergence from anesthesia and tracheal extubation
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