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Title of Journal: J Anesth

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Abbravation: Journal of Anesthesia

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Springer Japan

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DOI

10.1002/ange.19971091312

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ISSN

1438-8359

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Elevated postoperative inflammatory biomarkers are

Authors: Judith A Hudetz Sweeta D Gandhi Zafar Iqbal Kathleen M Patterson Paul S Pagel
Publish Date: 2010/11/09
Volume: 25, Issue: 1, Pages: 1-9
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Abstract

We tested the hypothesis that elevated postoperative interleukin6 IL6 and Creactive protein CRP concentrations are associated with short and mediumterm impairment of cognitive functions in patients after coronary artery surgery using cardiopulmonary bypassEightysix age and educationbalanced patients ≥55 years of age undergoing elective coronary artery bypass surgery with cardiopulmonary bypass and 28 nonsurgical controls with coronary artery disease were enrolled Recent verbal and nonverbal memory and executive functions were assessed before surgery and at 1 week and 3 months after surgery using a cognitive test battery IL6 concentrations were measured before surgery and 4 h after cardiopulmonary bypass and CRP concentrations were measured before surgery and at 24 and 72 h after anesthetic induction Overall cognitive function between high and low biomarker concentration groups was analyzed by the Wilcoxon ranksum testRecent memory was at least 1 standard deviation SD impaired at 1 week and 3 months in the highCRP compared with lowCRP and in the highIL6 compared with lowIL6 concentration groups Overall cognitive function was significantly P = 004 and P = 001 respectively different between the high and lowCRP concentration groups CRP assayed 24 h after anesthetic induction at both 1 week and 3 months Overall cognitive function was also significantly P = 004 different between the high and lowIL6 concentration groups at 1 week after surgery

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  14. The effect of body mass index on the spread of spinal block in patients with rheumatoid arthritis
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