Authors: Satoki Inoue Takeaki Shinjo Masahiko Kawaguchi Yoshiyuki Nakajima Hitoshi Furuya
Publish Date: 2011/09/17
Volume: 25, Issue: 6, Pages: 850-854
Abstract
Previous studies have demonstrated that amino acid infusions exert enhanced thermogenic effects during general anesthesia This study was conducted to investigate whether amino acid infusions started after development of intraoperative core hypothermia can accelerate rewarmingTwentytwo patients scheduled for major abdominal surgery were included in this study When tympanic temperature reached 355°C patients were randomly assigned to receive amino acids amino acid group n = 11 or saline saline group n = 11 A continuous infusion of a mixture of 18 amino acids or saline was started at 200 ml h−1 Tympanic forearm and digit temperatures were recorded Forearm minus fingertip skinsurface temperature gradients temperature gradient were calculated Postoperative shivering was also evaluatedTympanic membrane temperature and temperature gradient were similar between the two groups at each time point during the study period Temperature gradient at extubation in the amino acid group was significantly lower than in the saline group although tympanic temperature at extubation was similar between the two groups Postoperative shivering score was significantly lower in the amino acid group than in the saline groupAmino acid infusions started after development of intraoperative core hypothermia failed to accelerate rewarming However amino acid infusions reduced the incidence of postoperative shivering Use of amino acid infusions to reduce thermoregulatory vasoconstriction at emergence might contribute to a decrease in the development of postoperative shivering
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