Authors: Haitang Wang Yehua Cai Jingchen Liu Yinv Dong Jian Lai
Publish Date: 2015/07/18
Volume: 29, Issue: 6, Pages: 904-911
Abstract
Recent studies have shown that pain sensitivity has a significant relationship with clinical pain and may also predict the intensity of pain and analgesic consumption after surgery However the correlation between preoperative pain sensitivity and stress response during anesthesia has not been investigated Therefore we aimed to explore the relationship between preoperative pain sensitivity and stress responses during intubation and skin incision in this studyFifty women ASA I–II aged 20–55 years undergoing elective abdominal surgery requiring at least a 10cmlong skin incision were studied Pain sensitivity including pain threshold and pain tolerance was measured before surgery In this study experimental pain was induced by potassium ion conducted via continuous current When patients reported feeling pain or acted to stop pain the intensity of the current was recorded to register pain threshold and pain tolerance The StateTrait Anxiety Inventory STAI was used to examine the preoperative mental status General anesthesia was induced with intravenous fentanyl and a targetcontrolled infusion of propofol Blood samples for norepinephrine NE detection were collected at 10 min after entering the operating theater immediately before intubation 2 min after intubation immediately before skin incision and 2 min after incision Mean arterial blood pressure MAP and heart rate HR were recorded at the same time Pearson’s correlation test SPSS 130 was then used to analyze the relationship between pain sensitivity and the changes in MAP HR and NE levelA total of fifty women were enrolled in the study Their preoperative pain threshold and pain tolerance were 090 ± 040 mA and 253 ± 077 mArespectively Changes in MAP HR and NE before and after intubation or skin incision were significantly related with preoperative pain tolerance P 005 however pain threshold was not correlated with changes in MAP HR and NE P 005 The STAI score did not correlate with the stress response either P 005
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