Authors: Takahiro Nonaka Marie Hara Chisato Miyamoto Michiko Sugita Tatsuo Yamamoto
Publish Date: 2016/02/16
Volume: 30, Issue: 3, Pages: 405-409
Abstract
Acetaminophen is known to be a relatively weak analgesic with fewer side effects than nonsteroidal antiinflammatory drugs NSAIDs This study aimed to determine whether intravenous iv acetaminophen produces comparable analgesic effects to those of flurbiprofen positive control drug an intravenously injectable NSAID after partial mastectomies The primary outcome assessed was pain intensity during the first 24 h after the operation and the secondary outcome was the satisfaction rating at dischargeAfter obtaining Institutional Ethics Committee approval a series of 40 consecutive female patients who were scheduled for partial mastectomies were enrolled Participants were randomly divided into two groups an acetaminophen 1000 mg × 3 group group A and a flurbiprofen 50 mg × 3 group group F Each drug was administered 15 min before the end of surgery and at 6 and 12 h after the operation Postoperative pain was evaluated using a 100mm visual analog scale VAS at 3 6 and 24 h postoperatively Satisfaction rating was evaluated on a 5point scale very good good well bad and very badVAS scores mm with movement in groups A and F at 3 6 and 24 h after the surgery were 22 vs 28 14 vs 24 and 12 vs 205 median respectively with no significant differences between the two groups Eighteen of 20 patients in group A and 20 of 20 patients in group F expressed a satisfaction rating of greater than good
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