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Title of Journal: J Anesth

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Abbravation: Journal of Anesthesia

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Springer Japan

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DOI

10.1007/s00234-008-0408-4

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1438-8359

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Time course of changes in cerebral blood flow velo

Authors: Hiroshi Hinohara Yuji Kadoi Kenichiro Takahashi Shigeru Saito Chikara Kawauchi Akio Mizutani
Publish Date: 2011/04/07
Volume: 25, Issue: 3, Pages: 409-414
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Abstract

We observed an increase in mean middle cerebral artery blood flow velocity V mca after tourniquet deflation during orthopedic surgery under sevoflurane anesthesia in patients with diabetes mellitus or previous stroke Eight controls seven insulintreated diabetic patients and eight previous stroke patients were studied Arterial blood pressure heart rate V mca arterial blood gases and plasma lactate levels were measured every minute for 10 min after tourniquet release in all patients V mca was measured using a transcranial Doppler probe V mca in all three groups increased after tourniquet deflation the increase lasting for 4 or 5 min However the degree of increase in V mca in the diabetic patients was smaller than that in the other two groups after tourniquet deflation at 2 min after tourniquet deflation control 585 ± 33 previous stroke 584 ± 46 diabetes 517 ± 23 P  005 compared with the other two groups In conclusion the degree of increase in V mca in diabetic patients is smaller than that in controls and patients with previous strokeThe authors wish to thank Forte Tokyo Japan for assistance with manuscript preparation in English This study was supported in part by grants to Dr Kadoi No 21591998 from the Japanese Ministry of Education Culture Sports Science and Technology

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