Authors: Joy Chen Jawad Ahmad
Publish Date: 2008/08/28
Volume: 23, Issue: 11, Pages: 1914-1916
Abstract
Druginduced hepatotoxicity is well recognized but can cause some diagnostic problems particularly if not previously reported The present case involves a 22yearold male who presented with jaundice and elevated liver enzymes after a course of cefdinir Omnicef® for streptococcal pharyngitis A diagnosis of druginduced liver injury was suspected but a liver biopsy was required after his jaundice worsened despite cessation of the presumed offending agent A short course of steroids was initiated and eventually the jaundice resolved This case highlights the need to suspect medicationinduced liver injury in cases of jaundice even if not previously reported In addition it illustrates the potential for adverse outcomes in situations where antibiotics are used inappropriately or where first line antibiotics are not used for routine infections We report a case of a young male who developed jaundice associated with cefdinir use with pathological confirmation of moderate cholestasis with portal and lobular mixed inflammation and focal bile duct injury consistent with druginduced liver injury
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