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Title of Journal: J GEN INTERN MED

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Abbravation: Journal of General Internal Medicine

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Springer-Verlag

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DOI

10.1007/s10826-007-9178-6

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1525-1497

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Predictors of Mortality in Patients with Stable CO

Authors: Cristóbal Esteban José M Quintana Myriam Aburto Javier Moraza Mikel Egurrola Pedro Pablo España Julio PérezIzquierdo Alberto Capelastegui
Publish Date: 2008/09/16
Volume: 23, Issue: 11, Pages: 1829-
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Abstract

The variables were age FEV1 dyspnea previous hospital admissions and emergency department visits for COPD packyears of smoking comorbidities body mass index and HRQoL measured by Saint George’s Respiratory Questionnaire SGRQ Chronic Respiratory Questionnaire CRQ and ShortForm 36 SF36 Logistic and Cox regression models were used to assess the influence of these variables on mortality and survivalFEV1OR 062 95 CI 05 to 075 dyspnea OR 192 95 CI 12 to 3 age OR 241 95 CI 16 to 36 previous hospitalization due to COPD exacerbations OR 153 12 to 2 and lifetime packyears OR 115 95 CI 11 to 12 were independently related to respiratory mortality Similarly these factors were independently related to allcause mortality with dyspnea having the strongest association OR 154 95 CI 11 to 22 HRQoL was an independent predictor of respiratory and allcause mortality only when dyspnea was excluded from the models except scores on the SGRQ were associated with allcause mortality with dyspnea in the modelAmong patients with stable COPD FEV1 was the main predictor of respiratory mortality and dyspnea of allcause mortality In general HRQoL was not related to mortality when dyspnea was taken into account and CRQ and SGRQ behaved in similar ways regarding mortality

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