Journal Title
Title of Journal: Med Chem Res
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Abbravation: Medicinal Chemistry Research
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Publisher
SP Birkhäuser Verlag Boston
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Authors: Bedia KoçyiğitKaymakçıoğlu Emine Elçin OruçEmre Seda Unsalan Sevim Rollas
Publish Date: 2008/10/08
Volume: 18, Issue: 4, Pages: 277-286
Abstract
A series of substitututed methylene/ethylene 4fluorophenylhydrazide derivatives 3a–p was synthesized with the aim of evaluating their antimycobacterial activity toward a strain of Mycobacterium tuberculosis H37Rv Their chemical structures were confirmed by 1Hnuclear magnetic resonance NMR and electrospray mass spectrometry ESMS spectral data and elemental analysis The in vitro antimycobacterial evaluation was performed according to the Tuberculosis Antimicrobial Acquisition and Coordinating Facility TAACF antituberculosis drug discovery program Compound 3a 4fluorobenzoic acid 26dichlorophenyl methylenehydrazide showed the highest inhibitory activity of all the compounds under studyThis research was supported by Scientific Research Projects Commission of Marmara University project number SAGBGS2706050138 The authors would like to thank Dr Joseph A Maddry from the Tuberculosis Antimicrobial Acquisition and Coordinating Facility TAACF Southern Research Institute for his assistance
Keywords:
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