Journal Title
Title of Journal: Med Chem Res
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Abbravation: Medicinal Chemistry Research
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Authors: Rosiane Mastelari Martins Marília D’Avila Farias Fernanda Nedel Claudio M P de Pereira Claiton Lencina Rafael Guerra Lund
Publish Date: 2016/08/02
Volume: 25, Issue: 10, Pages: 2360-2367
Abstract
Eugenol is the major phenolic component of clove essential oil and it has been used in medical and dental practice for its properties like analgesic local anesthetic and antioxidant It is known that eugenol can denature proteins and react with cell membrane phospholipids changing their permeability and inhibiting a great number of Gramnegative and Grampositive bacteria as well as different types of yeast Eugenol has ever demonstrated antimicrobial properties thus the search for the optimization through structural changes appears to be interesting for the development of new antimicrobials This study aimed to evaluate the antimicrobial activity and cytotoxic characteristics of eugenol analogs From natural eugenol 14 derivatives were obtained by typical acylation and alkylation Their antimicrobial activity was evaluated by the broth microdilution method The compounds were assessed against Staphylococcus aureus ATCC 19095 Enterococcus faecalis ATCC 4083 Escherichia coli ATCC29214 Pseudomonas aeruginosa ATCC 9027 Candida albicans ATCC 62342 and the following clinical isolates from the human oral cavity C albicans 3 C parapsilosis C glabrata C lipolytica and C famata Cytotoxicity against mouse embryonic fibroblast NIH/3T3 cell line was evaluated by MTT colorimetric assay The majority of compounds demonstrated significant antimicrobial activities In general the compounds presented very low or no cytotoxicity with an inhibitory ratio lower than 50 against NIH/3T3 cell lineThis work was supported in part by grants from “Fundação de Amparo à Pesquisa do Rio Grande do Sul” FAPERGS “Coordenação de Aperfeiçoamento de Pessoal de Nível Superior” CAPES and “Conselho Nacional de Desenvolvimento Científico e Tecnológico” CNPq Brazil
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