Journal Title
Title of Journal: Med Chem Res
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Abbravation: Medicinal Chemistry Research
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Publisher
Springer-Verlag
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Authors: Vachala Seekarajapuram Dinakaran Divya Jacob Jessy Elizabeth Mathew
Publish Date: 2011/11/25
Volume: 21, Issue: 11, Pages: 3598-3606
Abstract
Recently there has been an increased interest in the synthesis of pyrimidinone and their applications in medicinal chemistry Pyrimidinone derivatives represent one of the active classes of the compounds possessing a wide spectrum of biological activities such as antitumour antifungal antiinflammatory antibacterial etc This study utilises chalcones as starting compounds that are obtained by ClaisenSchmidt condensation These chalcones underwent cyclisation upon treatment with urea and thiourea in the presence of sodium hydroxide to obtain the corresponding pyrimidinones and pyrimidinethiones The structures of the synthesized compounds were investigated by means of UV IR 1H NMR and Mass spectral analysis The antioxidant activity of the compounds was measured by standard free radical scavenging assays DPPH Nitric oxide radicals The compounds with significant antioxidant activity were then screened for the in vivo antiinflammatory activity and it showed that the compounds ETT and DMT possess good activity as comparable to the standard All the synthesized compounds were evaluated for their in vitro anticancer activity by MTT assay among which compounds CLU and ETU showed significant activity against HeLa and HepG2 cell lines respectivelyThe authors Vachala SD and Divya J are thankful to AICTE and DST for providing the instrumental facilities FTIR and UV The authors are also thankful to Manipal University Manipal and Dr N Udupa Principal Manipal College of Pharmaceutical Sciences for providing all necessary facilities to carry out this study
Keywords:
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