Journal Title
Title of Journal: Med Chem Res
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Abbravation: Medicinal Chemistry Research
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Publisher
Springer-Verlag
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Authors: Kai Zhou Xiaomeng Wang Yizhi Zhao Yongxiao Cao Qiang Fu Sanqi Zhang
Publish Date: 2010/10/28
Volume: 20, Issue: 8, Pages: 1325-1330
Abstract
The antihypertensive activity of nitrendipine analogues can be improved by properly lengthening its alkyl chain in 3 or 5position Nitrendipine and its seven analogues were synthesized and their antihypertensive activities in spontaneously hypertensive rats SHR were evaluated by ig administration It was found that 5nheptyl 3methyl 26dimethyl43nitrophenyl14dihydropyridine35dicarboxylate ±5 exhibited the strongest antihypertensive effect amongst eight compounds +5nheptyl 3methyl 26dimethyl43nitrophenyl14dihydropyridine35dicarboxylate +5 was also prepared Antihypertensive activities of ±5 and +5 in SHR were compared The results showed that ±5 and +5 had a higher potency than nitrendipine and +isomer was 179fold the raceme at a dose of 2 mg/kg
Keywords:
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