Journal Title
Title of Journal: Med Chem Res
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Abbravation: Medicinal Chemistry Research
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Authors: Abdullah G ElSehemi Samir Bondock Yousry A Ammar
Publish Date: 2013/07/31
Volume: 23, Issue: 2, Pages: 827-838
Abstract
Many derivatives of naproxen containing a variety of pyrazolecarboxamides were synthesized through the reaction of naproxenoyl hydrazide with formylpyrazole acetylacetone enaminone Mannich base and arylhydrazonomalononitrile derivatives Also many derivatives of naproxen were synthesized through the reaction of naprexenoyl chloride with amine derivatives containing pyrazole moiety The synthesized compounds were screened for antiinflammatory analgesic and ulcerogenic activities Screening of antiinflammatory revealed that compound 5 having a 13diphenylpyrazol4yl moiety had the most promising activity Compounds 8 9 and 12 possessing 35dimethylpyrazol1yl 3phenylpyrazol1yl and 35diamino44methoxyphenylazopyrazol1yl groups respectively showed moderate activity Moreover compounds 8 and 12 showed higher analgesic activity than the reference drug In ulcerogenic effect compound 22 which has methoxphenyl pyrazoline moiety devoid of ulcerogenic effect
Keywords:
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