Journal Title
Title of Journal: Med Chem Res
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Abbravation: Medicinal Chemistry Research
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Authors: M S R Murty Kesur R Ram B Ramalingeswara Rao Rayudu Venkateswara Rao Mohana Rao Katiki Janapala Venkateswara Rao R Pamanji L R Velatooru
Publish Date: 2013/09/08
Volume: 23, Issue: 4, Pages: 1661-1671
Abstract
A series of 334substituted1cyclicaminepropylthio5substituted124triazoles 8a–m and 234substituted1cyclicaminepropyl5substituted24dihydro3H124triazole3thiones 9a–h were synthesized with good yields starting from corresponding carboxylic acids using two different methods The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines Six compounds had shown good anticancer activity The triazole derivatives 9d 8j and 8i were most potent particularly against U937 and HL60 cells The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinant of their biological activityThe authors are grateful to the Director Indian Institute of Chemical Technology Hyderabad India for the encouragement KRR BR RVR MRK RP and LRV are thankful to the Council of Scientific Industrial Research CSIR New Delhi India for the award of fellowships We thank CSIR for financial support under the 12th Five Year plan project “Affordable Cancer Therapeutics ACT” CSC 0301
Keywords:
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