Journal Title
Title of Journal: Med Chem Res
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Abbravation: Medicinal Chemistry Research
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Authors: HongJian Zhang ShiBen Wang Xiang Wen JinZi Li ZheShan Quan
Publish Date: 2016/05/13
Volume: 25, Issue: 7, Pages: 1287-1298
Abstract
A series of pyrido23dpyrimidine derivatives 4a–4n 5a–5n 6 and 7 were designed and synthesized as potential anticonvulsants and antidepressants Their pharmacological activities were evaluated by maximal electroshock test forced swimming test and tail suspension test in mice Pharmacological analyses showed that compounds 4benzyl68dimethylpyrido32etetrazolo15apyrimidin54Hone 4a and 43fluorobenzyl68dimethylpyrido32etetrazolo15apyrimidin54Hone 4e exhibited the greatest anticonvulsant activity PI 1202 and 1225 respectively 30 min after intraperitoneal injection and were more efficient than the reference drug carbamazepine In addition 44fluorobenzyl68dimethylpyrido32etetrazolo15apyrimidin54Hone 4f and 64fluorobenzyl24dimethylpyrido32e124triazolo43apyrimidin56Hone 5f possessed potent antidepressant properties that lead to significant reduction in the duration of the immobility time than did the control P 0001 which possessed activities similar to those of fluoxetine 4f showed obvious antidepressant activity at doses of 10 mg/kg
Keywords:
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