Journal Title
Title of Journal: Med Chem Res
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Abbravation: Medicinal Chemistry Research
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Authors: Vikas Sharma Vipin Kumar
Publish Date: 2014/02/27
Volume: 23, Issue: 8, Pages: 3593-3606
Abstract
The discovery of camptothecin and its analogs was the major breakthrough through which “Indolizine moiety” came into limelight Although major part of the research on indolizine derivatives is focused on anticancer drug discovery these derivatives have also been screened for different biological activities such as antitubercular antioxidant antimicrobial anticancer and antiinflammatory activities to name a few Despite being an important medicinal moiety a detailed review on the biologically active potential of indolizine derivative is unavailable To the best of our knowledge previous reviews on indolizine derivatives mainly focused on their chemistry and synthesis The present review discusses the versatile nature of indolizine derivatives and their possible mechanism of action Important SAR points are discussed with each study to highlight the rationale behind the study Furthermore the present review also provides information about current/future prospects of the topic and different indolizine derivatives in clinical trials
Keywords:
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